Manchester United lost ground at the top of the table as their former striker Joshua King scored the winner in Bournemouth's 2-1 triumph - the Cherries' second shock win in a week.
After David de Gea was beaten direct from a corner by Junior Stanislas, United equalised via Marouane Fellaini.
The visitors faded after the break and could not fight back after King fired in from Matt Ritchie's set-piece.
United will slip to fifth if Tottenham beat Newcastle on Sunday.
The scoreline and final few minutes could have been more comfortable for the hosts, but substitute Glenn Murray squandered two excellent chances to put Bournemouth further out of reach.
Bournemouth are up to 14th in the Premier League on the back of successive victories, having beaten defending champions Chelsea last weekend.
United boss Louis van Gaal bemoaned his options in attack last week, claiming that Barcelona's Luis Suarez or Manchester City's Sergio Aguero would convert the chances his strikers were missing.
It is difficult to imagine either player squandering the two fine openings that Anthony Martial - now without a goal in nine Premier League games - created for himself.
But United were lacking in plenty of other areas.
Daley Blind, the experienced head in a fresh-faced defence, was caught horribly out of position to allow Murray in on goal, the midfield created little and the team as a whole were out-fought by a spirited Cherries' side.
When Fellaini trudged off to be replaced by Nick Powell in the 74th minute, their best hope of a point went with him.
Bournemouth's victory at Stamford Bridge seven days ago was akin to a smash-and-grab raid based on 37% of possession, a sturdy defence and a well-executed set-piece.
But against United they were a constant danger on the counter with the pacey, intelligent runs of Stanislas off the wing posing a particular threat.
After his swirling delivery had caught out De Gea, Stanislas ran clean through, only for the United goalkeeper to make partial amends as he smothered at his feet.
Toffees and Cherries' sweet double |
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Bournemouth became only the second side to beat Chelsea and Manchester United in successive Premier League games. |
Everton also managed to do so in February 2010. |
King, who made two substitute appearances for United during his three and a half years at the club, had looked less assured in the Cherries attack, but guided in an awkward half-volley as a rehearsed corner routine came off for the hosts.
As the home fans constantly reminded their United counterparts, Bournemouth "come from League Two".
They came dangerously close to slipping even further down the divisions in the 2008-09 season as they successfully fought administration and relegation to the Conference.
At the same time United were lifting a third successive Premier League title under the guidance of Sir Alex Ferguson.
United chief executive Ed Woodward, who watched on stony-faced in the Vitality Stadium stands, will not enjoy the contrast in fortunes now.
Bournemouth midfielder Harry Arter played for 86 minutes just a few days after he and his partner's child died at birth.
"It's been a really tough week for Harry and his family, hugely emotional," said Bournemouth boss Eddie Howe.
"He's handled himself with real dignity and to play the way he did, I can't credit him enough. He showed great strength.
"Harry wanted to play, I had to make an assessment of him but once I'd spoken to him there was no doubt I was going to play him."
Bournemouth manager Eddie Howe: "We try not to focus on the injuries we've had.
"We still believe we're strong enough. Hopefully the last few games is the proof.
"We've looked at the last few games as turning points - we're looking at this run as hopefully something of a start for us."
Manchester United manager Louis van Gaal: "The attitude of the players I liked. But that is not the only important thing - you have to perform in a certain way.
"It is always very disappointing when you are at the top of the table when you lose to a club at the bottom of the table."
"We're an institution - we stick by our managers"
Manchester United fan Stephen called BSports 606 to defend the tenure of manager Louis van Gaal.
Bournemouth will play West Brom, currently one place above them, away next Saturday. Manchester United meet Norwich at home on the same day, before a Boxing Day trip to Stoke and a home match against Chelsea on 28 December.
Full Time Match ends, Bournemouth 2, Manchester United 1.
90:00 +6:28 Full timeFull Time Second Half ends, Bournemouth 2, Manchester United 1.
90:00 +5:46 BookingBooking Artur Boruc (Bournemouth) is shown the yellow card.
90:00 +5:01Offside, Manchester United. David de Gea tries a through ball, but Juan Mata is caught offside.
90:00 +4:11Foul by Phil Jones (Manchester United).
90:00 +4:11Glenn Murray (Bournemouth) wins a free kick in the defensive half.
90:00 +0:45 SubstitutionSubstitution Substitution, Manchester United. Phil Jones replaces Patrick McNair.
90:00 +0:16Hand ball by Charlie Daniels (Bournemouth).
88:07Foul by Patrick McNair (Manchester United).
88:07Dan Gosling (Bournemouth) wins a free kick on the left wing.
85:45 SubstitutionSubstitution Substitution, Bournemouth. Eunan O'Kane replaces Harry Arter.
83:52 BookingBooking Harry Arter (Bournemouth) is shown the yellow card.
83:41Delay over. They are ready to continue.
82:36Delay in match Andrew Surman (Bournemouth) because of an injury.
80:07Anthony Martial (Manchester United) wins a free kick on the right wing.
80:07Foul by Junior Stanislas (Bournemouth).
79:30Attempt missed. Harry Arter (Bournemouth) left footed shot from outside the box misses to the left. Assisted by Dan Gosling.
77:52Patrick McNair (Manchester United) wins a free kick in the defensive half.
77:52Foul by Glenn Murray (Bournemouth).
76:38Attempt missed. Anthony Martial (Manchester United) left footed shot from the centre of the box is high and wide to the left.
Attempt blocked. Michael Carrick (Manchester United) right footed shot from outside the box is blocked.
73:27 SubstitutionSubstitution Substitution, Manchester United. Nick Powell replaces Marouane Fellaini.
72:51Anthony Martial (Manchester United) wins a free kick on the left wing.
72:51Foul by Simon Francis (Bournemouth).
72:18Attempt missed. Glenn Murray (Bournemouth) left footed shot from the centre of the box is too high following a corner.
71:46Corner, Bournemouth. Conceded by Guillermo Varela.
71:23Foul by Marouane Fellaini (Manchester United).
71:23Matt Ritchie (Bournemouth) wins a free kick on the right wing.
70:43Attempt missed. Glenn Murray (Bournemouth) left footed shot from the centre of the box is too high. Assisted by Dan Gosling.
68:52Foul by Cameron Borthwick-Jackson (Manchester United).
68:52Adam Smith (Bournemouth) wins a free kick in the defensive half.
65:48Guillermo Varela (Manchester United) wins a free kick in the defensive half.
65:48Foul by Glenn Murray (Bournemouth).
64:44 SubstitutionSubstitution Substitution, Bournemouth. Glenn Murray replaces Joshua King because of an injury.
64:37Delay over. They are ready to continue.
63:58Delay in match Joshua King (Bournemouth) because of an injury.
63:01Marouane Fellaini (Manchester United) wins a free kick in the defensive half.
63:01Foul by Adam Smith (Bournemouth).
60:14Attempt blocked. Marouane Fellaini (Manchester United) left footed shot from the centre of the box is blocked.
59:47Corner, Manchester United. Conceded by Artur Boruc.
59:23Corner, Manchester United. Conceded by Harry Arter.
59:21Attempt blocked. Marouane Fellaini (Manchester United) right footed shot from the centre of the box is blocked.
57:17Foul by Memphis Depay (Manchester United).
57:17Matt Ritchie (Bournemouth) wins a free kick on the right wing.
56:27Corner, Manchester United. Conceded by Steve Cook.
56:02Corner, Manchester United. Conceded by Adam Smith.
55:58Attempt saved. Marouane Fellaini (Manchester United) right footed shot from the centre of the box is saved in the centre of the goal.
53:42 Goal scoredGoal! Goal! Bournemouth 2, Manchester United 1. Joshua King (Bournemouth) right footed shot from the centre of the box to the centre of the goal. Assisted by Matt Ritchie following a corner.
53:10Corner, Bournemouth. Conceded by David de Gea.
53:08Attempt saved. Simon Francis (Bournemouth) right footed shot from a difficult angle on the right is saved in the bottom right corner. Assisted by Steve Cook.
49:40Marouane Fellaini (Manchester United) wins a free kick in the attacking half.
49:40Dangerous play by Matt Ritchie (Bournemouth).
48:23Delay over. They are ready to continue.
47:22Delay in match Junior Stanislas (Bournemouth) because of an injury.
45:00Second Half begins Bournemouth 1, Manchester United 1.
45:00 +2:18 Half timeHalf Time First Half ends, Bournemouth 1, Manchester United 1.
45:00 +1:47Attempt missed. Matt Ritchie (Bournemouth) header from the centre of the box misses to the left. Assisted by Joshua King with a cross.
44:20Delay over. They are ready to continue.
43:34Delay in match Steve Cook (Bournemouth) because of an injury.
43:12Foul by Juan Mata (Manchester United).
43:12Dan Gosling (Bournemouth) wins a free kick in the defensive half.
41:33Attempt saved. Matt Ritchie (Bournemouth) left footed shot from outside the box is saved in the centre of the goal. Assisted by Joshua King.
40:42 BookingBooking Andreas Pereira (Manchester United) is shown the yellow card for a bad foul.
40:29Foul by Andreas Pereira (Manchester United).
40:29Junior Stanislas (Bournemouth) wins a free kick in the defensive half.
39:16Corner, Manchester United. Conceded by Simon Francis.
37:19Andreas Pereira (Manchester United) wins a free kick in the defensive half.
37:19Foul by Dan Gosling (Bournemouth).
36:21Memphis Depay (Manchester United) wins a free kick in the defensive half.
36:21Foul by Adam Smith (Bournemouth).
33:00Attempt missed. Joshua King (Bournemouth) left footed shot from the centre of the box misses to the left. Assisted by Junior Stanislas.
30:27 SubstitutionSubstitution Substitution, Manchester United. Andreas Pereira replaces Jesse Lingard because of an injury.
29:03Delay over. They are ready to continue.
28:09Delay in match Jesse Lingard (Manchester United) because of an injury.
27:00Attempt saved. Junior Stanislas (Bournemouth) right footed shot from outside the box is saved in the bottom left corner. Assisted by Harry Arter.
26:42Corner, Bournemouth. Conceded by Patrick McNair.
26:09Corner, Bournemouth. Conceded by Michael Carrick.
24:50Offside, Manchester United. Michael Carrick tries a through ball, but Memphis Depay is caught offside.
23:34 Goal scoredGoal! Goal! Bournemouth 1, Manchester United 1. Marouane Fellaini (Manchester United) right footed shot from very close range to the centre of the goal.
23:30Attempt saved. Memphis Depay (Manchester United) right footed shot from the centre of the box is saved in the centre of the goal. Assisted by Michael Carrick.
22:28Foul by Marouane Fellaini (Manchester United).
22:28Joshua King (Bournemouth) wins a free kick in the defensive half.
21:00Memphis Depay (Manchester United) wins a free kick on the left wing.
21:00Foul by Adam Smith (Bournemouth).
17:17Attempt missed. Anthony Martial (Manchester United) right footed shot from outside the box is close, but misses to the left.
16:04Daley Blind (Manchester United) wins a free kick in the defensive half.
16:04Foul by Joshua King (Bournemouth).
14:47Offside, Bournemouth. Junior Stanislas tries a through ball, but Joshua King is caught offside.
14:14Foul by Marouane Fellaini (Manchester United).
14:14Adam Smith (Bournemouth) wins a free kick in the defensive half.
13:00Attempt missed. Junior Stanislas (Bournemouth) right footed shot from outside the box is too high from a direct free kick.
12:09Foul by Daley Blind (Manchester United).
12:09Joshua King (Bournemouth) wins a free kick in the attacking half.
9:16Foul by Marouane Fellaini (Manchester United).
9:16Adam Smith (Bournemouth) wins a free kick in the defensive half.
7:32Corner, Manchester United. Conceded by Harry Arter.
5:07Attempt missed. Patrick McNair (Manchester United) right footed shot from the centre of the box misses to the left. Assisted by Daley Blind with a cross following a corner.
4:48Corner, Manchester United. Conceded by Steve Cook.
4:42Attempt saved. Patrick McNair (Manchester United) header from the centre of the box is saved in the bottom right corner.
4:38Attempt saved. Marouane Fellaini (Manchester United) left footed shot from the centre of the box is saved in the top centre of the goal.
3:52Memphis Depay (Manchester United) wins a free kick on the left wing.
3:52Foul by Adam Smith (Bournemouth).
1:40 Goal scoredGoal! Goal! Bournemouth 1, Manchester United 0. Junior Stanislas (Bournemouth) right footed shot from a difficult angle and long range on the left to the top right corner following a corner.
1:19Corner, Bournemouth. Conceded by Michael Carrick.
0:41Joshua King (Bournemouth) wins a free kick on the left wing.
0:41Foul by Guillermo Varela (Manchester United).
0:00First Half begins.
0:00Lineups are announced and players are warming up.
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