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Stoke will be without skipper Ryan Shawcross for the League Cup quarter-final after he was dismissed in the loss to Sunderland.
Shay Given (knee) and Marc Muniesa (hamstring) are also unavailable.
Sheffield Wednesday head coach Carlos Carvalhal is without key midfielder Barry Bannan (knee) for the trip to the Potteries.
Youngster Joe Wildsmith is likely to start in goal, while loan striker Gary Hooper is also eligible.
Stoke boss Mark Hughes: "We won't underestimate Sheffield Wednesday in any way, shape or form. If you look at their progression in the competition they have beaten two Premier League sides already.
"We're at home and when the draw was made if we're honest enough we can say they were one of the teams we wanted to have.
"You can't argue about that. If we're going to progress it should be in our favour."
Sheffield Wednesday head coach Carvalhal: "It will be cold and there will be rain probably. It's not a good day to go to the football. There will be 4,000 fans in the rain and cold and they pay for a ticket to see us play. This means we must play to them.
"It happened at Blackburn on Saturday and it will happen again. We must play to all the fans. We will give 300%, give everything on the pitch and we will do that."