Walsall interim boss Jon Whitney is set to make changes as the Saddlers aim to make play-off history by overturning a three-goal, first-leg deficit.
Following Saturday's 3-0 loss at Oakwell, midfielder Sam Mantom and on-loan striker Jordy Hiwula may come in.
Johnstone's Paint Trophy winners Barnsley are looking to book their second trip to Wembley this season.
Caretaker boss Paul Heckingbottom is injury free and can name the same starting XI for a fifth straight game.
Barnsley have already triumphed once at Bescot this season, having run out 3-1 winners in the league meeting in early March.
But Walsall did taste victory against the Tykes in the first of this season's four meetings between the two sides, winning 2-0 at Oakwell in October.
Walsall interim head coach Jon Whitney told BSports WM:
"It's a big ask, a huge task. Everyone says you have to make history to come from three goals down but we have to give it a go.
"Of course we'd love to be going in with a 1-0 lead, but that's in the past now.
"We can't go in gung ho. We still have to keep a clean sheet. It's just about wanting to win and showing a lot of passion and desire.
"The players have to look within. Whatever it takes for them to get motivated, they have to do it. If it has to come from me, we have a huge problem."
Barnsley caretaker head coach Paul Heckingbottom told BSports Radio Sheffield:
"The players have the mentality to go out to win and that will be exactly the same.
"We saw how Brighton set about Sheffield Wednesday. That could have changed the whole outcome of the game but it didn't and we have to have that mentality as well.
"If any goal against us we have to fight it back and try and win the game. Our mentality has been the same in every single game and we will continue to do it.
"They will be coming at us at some stage but it's another game and we have to win it, regardless of what's in front of us."
Walsall have won four of their last five home league matches - but they lost 3-1 to Barnsley when the Tykes last visited Bescot in March.
The Tykes are unbeaten in eight games on the road, having conceded only five goals in their last 12 League One away games, keeping eight clean sheets in the process.
Walsall, who need at least three goals to progress to the final, have scored more than twice on only two occasions at the Banks's Stadium this season.
Sam Winnall's first-leg brace was the second successive game in which he has scored twice - coming on the back of a run in which he had scored in only two of Barnsley's previous 14 games.
The Saddlers have won only one of their three previous play-off semi-final second-leg ties, when they beat Stoke City 4-2 at Bescot on the way to promotion to the second tier in 2001.